Parthenolide attenuated bleomycin-induced pulmonary fibrosis via the NF-κB/Snail signaling pathway
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چکیده
منابع مشابه
Dexamethasone suppresses bleomycin-induced pulmonary fibrosis via down-regulation of jagged1/notch1 signaling pathway
Dexamethasone (DEX) plays an important role in attenuating bleomycin (BLM)-induced lung fibrosis in mice. Recently, inhibition of Notch signaling is a potential therapeutic strategy for pulmonary fibrosis. To investigate whether dexamethasone exerts protective effect on BLM-induced pulmonary fibrosis via inhibiting the Notch signaling, BLM-induced rat model was used. All SD rats received daily ...
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Background: Bleomycin-induced lung fibrosis has been accepted as an animal model for fibrosis in rats. The aim of this study was to evaluate the effects of saffron aqueous extract on this disorder paving the way for more investigation in treating idiopathic pulmonary fibrosis in human. Methods: Male Wistar rats (250–300 gr) were instilled a single dose of bleomycin (5 mg/kg) via in...
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The administration of doxycycline prior to bleomycin in mice attenuated pulmonary fibrosis. Bronchoalveolar neutrophil influx and gelatinase activity, but not caseinolytic activity, were attenuated by doxycycline. Established fibrosis was not affected by doxycycline. Thus, doxycycline might be useful for slowing down pulmonary fibrosis by biological activity other than antibacterial activity.
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Objective(s): This study aims to investigate the pathogenicity and possible mechanisms of S100A9 function in mice models of scleroderma. Materials and Methods: The content of S100A9 in the skin tissues of mice with scleroderma was determined. Different concentrations of bleomycin (BLM) and S100A9 were subcutaneously injected into the backs of mice simultaneously, and then pathological changes i...
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BACKGROUND Baicalin has been reported to have anti-fibrosis effect; however, its mechanism still remains to be elucidated. Adenosine A2a receptor (A2aR) is a novel inflammation regulator, and transforming growth factor-β1 (TGF-β1)-induced extracellular signal regulated kinase1/2 (ERK1/2) signaling pathway plays an important role in idiopathic pulmonary fibrosis (IPF). This study was to explore ...
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ژورنال
عنوان ژورنال: Respiratory Research
سال: 2018
ISSN: 1465-993X
DOI: 10.1186/s12931-018-0806-z